RESEARCH SCIENTIST/ENGINEER 4
University of Washington
Seattle, WA
Full-time
Engineering
Posted on June 13, 2019
Req #: | 168423 |
Department: | ANESTHESIOLOGY AND PAIN MEDICINE |
Job Location: | South Lake Union |
Posting Date: | 06/11/2019 |
Closing Info: | Closes On 06/18/2019 |
Salary: | Salary is commensurate with education and experience |
Limited Recruitment: |
Open to UW Employees only
If you are a UW employee and would like to be considered for this position, please login to your UW employee profile to apply. |
Shift: | First Shift |
Notes: | As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here. |
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a “Great College to Work For” for four consecutive years.
The Department of Anesthesiology and Pain Medicine currently has an outstanding opportunity for a RESEARCH SCIENTIST ENGINEER 4.
The Crowder lab, which is part of the Mitochondrial & Metabolism Center within the Department of Anesthesiology & Pain Medicine, looks at the genetic determinants of cellular injury after environmental stress. The lab is focused primarily on hypoxic cellular injury:
1. Cell death after hypoxia in the form of heart attacks and strokes is the number one cause of mortality in the United States. Additionally, resistance to hypoxic cell death is a significant contributor to cancer cell metastasis and tumor growth.
2. We use genetic and small molecule screens as discovery tools to identify novel determinants of hypoxic injury and survival.
The Crowder lab is looking for a Research Scientist who has education and substantial experience working in research that affects the mitochondria; specifically in the area of genetic determinants of cellular injury after environmental stress. The Scientist must be familiar with the concept of mitochondrial protein misfolding as both a possible consequence of hypoxia and a cause of hypoxic cell injury and death.
This Scientist must be familiar with using Caenorhabditis elegns, (C. elegans), a genetically tractable soil nematode as a primary model to understand the complex mechanism whereby cells survive or die after hypoxia. Where possible, the Crowder lab uses C. elegans for the fundamental discovery and application to mammalian models of hypoxic disease. The Crowder lab has found that mitochondria protein folding, the protein translation machinery, and an insulin-like growth factor receptor are very powerful determinants of hypoxic death and survival.
The Scientist must be or become expert at generating transgenic lines and other complex genetic manipulations needed to test hypotheses of the role of particularly genes in hypoxic injury. The Scientist must be familiar with and able to form testable and informative hypotheses and then develop the methods and conduct the experiments to test these hypotheses. The Scientist must have experience in analyzing data from these experiments and putting data and conclusions into publishable form.
Research Duties: 90%
The type of research, knowledge and skills are above. This Scientist will perform the following duties in the context of the research goals:
Minimum Requirements:
Specific knowledge, skills and abilities required to perform the job satisfactorily include:
Other Required Qualifications:
Desired Requirements:
Application Process:
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
The University of Washington is a leader in environmental stewardship & sustainability, and committed to becoming climate neutral.
The University of Washington is an equal opportunity, affirmative action employer. To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 / 206-543-6452 (tty) or dso@uw.edu.
If you are a UW employee and would like to be considered for this position, please login to your UW employee profile to apply.